Trimethobenzamide
Trimethobenzamide is an antiemetic medication used to prevent and treat nausea and vomiting. It acts on the chemoreceptor trigger zone in the brain to reduce nausea and vomiting impulses. This medication is typically prescribed for patients experiencing nausea and vomiting from various causes.
Trimethobenzamide is an antiemetic that prevents and treats nausea and vomiting by acting on the chemoreceptor trigger zone in the brain.
Key facts at a glance
- ATC
- R06AA10
- RxNorm
- 38685
- Generic
- Trimethobenzamide
- Class
- atc-r06
- Brands
- Tigan
- Availability
- rx
- Lactation
- unknown
- Routes
- rectal, oral
- Forms
- injection, capsule, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
11 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
third trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingdiscontinue breastfeeding or avoid drug
do not use during breastfeeding - drug passes into breast milk
monitor infant for excessive drowsiness
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderlyuse lowest effective dose
use with caution due to increased sensitivity to anticholinergic effects and sedation
monitor for dizziness, sedation, and fall risk
Use with caution and monitor for adverse effects.
pediatric_age
infants and childrennot recommended
not approved for use in children - contraindicated in infants and young children
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
mild to moderatereduce dose by 25-50%
use with caution - drug is primarily excreted by kidneys
monitor renal function and adjust dose accordingly
Use with caution and monitor for adverse effects.
renal_impairment
severeavoid use
avoid in severe renal impairment due to accumulation risk
monitor renal function closely
Use of this medication in this population requires careful consideration of risks and benefits.
hepatic_impairment
mild to moderatereduce dose by 25-50%
use with caution - drug is metabolized in liver
monitor liver function tests
Use with caution and monitor for adverse effects.
hepatic_impairment
severeavoid use
avoid in severe hepatic impairment
monitor liver function closely
Use of this medication in this population requires careful consideration of risks and benefits.
alcohol_users
concurrent useavoid alcohol
contraindicated with alcohol use - significantly increases CNS depression
avoid alcohol completely during treatment
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Available formulations
Formulation availability
Trimethobenzamide is used to prevent and treat nausea and vomiting associated with various conditions, including post-operative nausea, chemotherapy-induced nausea, and other causes of vomiting.
The exact mechanism is not fully understood, but trimethobenzamide is believed to work by acting on the chemoreceptor trigger zone (CTZ) in the medulla oblongata, blocking emetic impulses from reaching the vomiting center. It may also exert direct effects on the vomiting center itself.
As with all antiemetics, trimethobenzamide should be used under medical supervision. It may cause drowsiness, and patients should avoid driving or operating machinery until they know how the medication affects them. Patients with a history of allergic reactions to trimethobenzamide or similar medications should not use this drug. Always consult a healthcare provider for appropriate use and dosing.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy