Vortioxetine
Trintellix (vortioxetine) is a multimodal antidepressant used to treat major depressive disorder in adults. Unlike typical antidepressants that work through a single mechanism, Trintellix targets multiple serotonin receptors and transporters simultaneously, which may provide efficacy for patients who haven't responded to other antidepressants.
Trintellix is a prescription antidepressant for adults with major depressive disorder that works through multiple serotonergic pathways.
Key facts at a glance
- RxNorm
- 1790881
- Generic
- Trintellix
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trintellix is FDA-approved for the treatment of major depressive disorder (MDD) in adults. It may be prescribed when other antidepressants have been ineffective or poorly tolerated.
Trintellix is a serotonin modulator and stimulator that works through multiple mechanisms: it inhibits serotonin reuptake (like an SSRI) while also modulating various serotonin receptors. This multimodal approach distinguishes it from traditional antidepressants.
Trintellix carries a boxed warning about increased suicidal thoughts in young adults under 25. It should not be taken with MAOIs or within 14 days of stopping one. Common side effects may include nausea, headache, and dizziness. Always take as prescribed and discuss all medications with your healthcare provider to avoid dangerous interactions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy