Tripelennamine
Tripelennamine is a first-generation antihistamine medication historically used to treat allergic conditions such as hay fever, itching, and skin allergies. It works by blocking histamine H1 receptors, which reduces allergic symptoms like sneezing, itching, and runny nose. Due to its sedative properties and the availability of newer, less sedating alternatives, it is less commonly prescribed today.
Tripelennamine is an older antihistamine used for allergies that has largely been replaced by less sedating options.
Key facts at a glance
- ATC
- R06AA02
- RxNorm
- 2124
- Generic
- Tripelennamine
- Class
- atc-d04
- Brands
- Re-Covr
- Availability
- otc
- Pregnancy
- C
- Lactation
- caution
- Half-life (h)
- 4
- Onset (min)
- 45
- Duration (h)
- 6
- Routes
- topical, oral
- Forms
- tablet, syrup, liquid, cream
- Regions
- United States, Canada, United Kingdom, Australia
- Monitoring
- sedation, dry mouth, urinary retention
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tripelennamine has been used to treat allergic rhinitis, hay fever symptoms, itching (pruritus), and various skin allergic reactions. It may also have been used for allergic conjunctivitis symptoms.
As a first-generation H1 antihistamine, tripelennamine blocks histamine H1 receptors in the body, preventing histamine from causing allergic symptoms. It also has anticholinergic properties.
First-generation antihistamines like tripelennamine commonly cause drowsiness and should be used with caution when driving or operating machinery. They may also cause dry mouth, blurred vision, and urinary retention. This medication is generally not recommended for use in children or the elderly without medical supervision. Always consult a healthcare provider before using any antihistamine.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy