Triprolidine
Triprolidine is a first-generation antihistamine that provides relief from allergy symptoms by blocking histamine H1 receptors. It is commonly used to treat seasonal allergies, allergic rhinitis, and cold symptoms such as sneezing, runny nose, and itchy eyes.
A sedating antihistamine used to relieve allergic symptoms like sneezing, itching, and runny nose.
Key facts at a glance
- ATC
- R06AX07
- RxNorm
- 10811
- Generic
- Triprolidine
- Class
- atc-r06
- Brands
- Wal-Act, A-Phedrin, Aphedrid, Genac brand of pseudoephedrine/triprolidine, Pediaclear Childrens, Vi-Sudo, Flonase Nighttime
- Availability
- otc
- Pregnancy
- C
- Lactation
- caution
- Half-life (h)
- 4
- Onset (min)
- 30
- Duration (h)
- 6
- Routes
- oral
- Forms
- tablet, film-coated tablet, syrup, oral solution
- Regions
- United States, Canada, United Kingdom, Australia, New Zealand, Ireland, South Africa
- Monitoring
- sedation, anticholinergic effects
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 2.5mg-5mg
- Maximum
- consult physician
- Frequency
- every 4-6 hours as needed
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 1.25mg-2.5mg
- Maximum
- consult physician
- Frequency
- every 4-6 hours as needed
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 2.5mg
- Maximum
- consult physician
- Frequency
- every 4-6 hours as needed
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
10 groupspregnancy
first trimesteravoid if possible
use only if benefits outweigh potential risks to fetus
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimesteruse lowest effective dose
use only if clearly needed
standard prenatal care
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid close to delivery
avoid use near term due to potential effects on newborn
fetal monitoring in late pregnancy
Use with caution and monitor for adverse effects.
lactation
breastfeedingavoid or use lowest dose
drug passes into breast milk, monitor infant for sedation
observe infant for excessive drowsiness
Use with caution and monitor for adverse effects.
geriatric
elderlyreduce dose, start low
increased sensitivity to anticholinergic effects, risk of falls and confusion
monitor for anticholinergic effects, cognitive changes
Use with caution and monitor for adverse effects.
pediatric_age
infants and toddlersnot recommended
do not use in children under 2 years due to risk of respiratory depression
emergency medical attention if respiratory distress occurs
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
childrenweight-based dosing, do not exceed recommended
use with caution in children 2-12 years, avoid in asthma
monitor for paradoxical excitement or sedation
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderatemay need dose reduction
use with caution, monitor for increased sedation
monitor renal function and drug response
Use with caution and monitor for adverse effects.
hepatic_impairment
moderatereduce dose
use with caution due to reduced metabolism
monitor liver function and clinical response
Use with caution and monitor for adverse effects.
alcohol_users
concurrent useavoid combination
do not consume alcohol with triprolidine
none - avoid completely
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Drug class
Triprolidine belongs to the ethanolamine class of first-generation H1 antihistamines
Common uses
Triprolidine is used as an antihistamine for relief of sneezing, runny nose, and watery eyes
Commonly prescribed since
Triprolidine has been on the market for over 70 years
Typical formulation
Triprolidine is commonly formulated in combination products with pseudoephedrine (decongestant) for cold and allergy relief
Relief of symptoms associated with allergic conditions including hay fever, allergic rhinitis, urticaria (hives), and common cold symptoms such as sneezing and runny nose. Often combined with decongestants for enhanced symptom relief.
Blocks histamine H1 receptors in the body, preventing histamine from binding and causing allergic responses. This reduces symptoms like itching, sneezing, nasal discharge, and watery eyes. It has anticholinergic properties that also help dry respiratory secretions.
May cause drowsiness and should be used with caution when driving or operating machinery. Alcohol and other CNS depressants may enhance sedation. Should be avoided in patients with narrow-angle glaucoma, urinary retention, or severe hypertension. Consult a healthcare provider before use during pregnancy or breastfeeding.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy