Arsenic Trioxide
Trisenox (arsenic trioxide) is an anticancer medication primarily used to treat a specific type of leukemia called acute promyelocytic leukemia (APL), particularly in patients who have not responded to other treatments or have experienced relapse. It works by targeting and destroying cancer cells in the blood and bone marrow. This medication is administered under close medical supervision in a clinical setting due to its potent effects and potential serious side effects.
Trisenox is a chemotherapy agent used to treat relapsed or refractory acute promyelocytic leukemia (APL) by targeting and eliminating cancer cells.
Key facts at a glance
- RxNorm
- 829877
- Generic
- Trisenox
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trisenox is FDA-approved for the treatment of acute promyelocytic leukemia (APL) in patients who have relapsed after prior treatment or are refractory to conventional therapies. It may be used alone or in combination with other medications as part of a prescribed treatment regimen.
Arsenic trioxide, the active ingredient in Trisenox, works by causing damage to the DNA of abnormal leukemia cells, which triggers programmed cell death (apoptosis). It helps the body eliminate the cancerous cells that accumulate in the blood and bone marrow during APL.
Trisenox can cause serious side effects including differentiation syndrome (fever, difficulty breathing, weight gain), heart rhythm abnormalities (QT prolongation), and liver problems. Regular monitoring of blood counts, heart function, and electrolytes is required during treatment. It should only be administered by healthcare professionals experienced in chemotherapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy