Troglitazone
Troglitazone was a thiazolidinedione medication used to treat type 2 diabetes mellitus by improving insulin sensitivity through PPAR-gamma receptor activation.
Troglitazone was a diabetes medication withdrawn from the market due to serious liver toxicity risks.
Key facts at a glance
- ATC
- A10BG01
- RxNorm
- 72610
- Generic
- Troglitazone
- Class
- atc-a10
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Troglitazone was indicated for the treatment of type 2 diabetes mellitus, particularly in patients with insulin resistance who had inadequate glycemic control with diet and exercise alone or with other antidiabetic medications.
Troglitazone worked by activating peroxisome proliferator-activated receptor gamma (PPAR-gamma), which is primarily found in adipose tissue. This activation increased insulin sensitivity in muscle, liver, and fat cells, reduced hepatic glucose production, and enhanced peripheral glucose uptake.
Troglitazone was withdrawn from the market in 2000 due to reports of severe hepatotoxicity, including acute liver failure requiring transplantation. It required regular liver function monitoring and was contraindicated in patients with pre-existing liver disease. Rosiglitazone and pioglitazone are later-generation thiazolidinediones that replaced it.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy