Tropisetron
Tropisetron is a serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting, particularly following chemotherapy or surgical procedures, by blocking serotonin receptors in the chemotherapy.
Tropisetron is an antiemetic medication used to prevent chemotherapy and surgery-related nausea and vomiting by blocking serotonin receptors.
Key facts at a glance
- ATC
- A04AA03
- RxNorm
- 27392
- Generic
- Tropisetron
- Class
- atc-a04
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of acute nausea and vomiting associated with chemotherapy (particularly moderately emetogenic regimens), prevention and treatment of postoperative nausea and vomiting. May be used when patients have inadequate response to first-line antiemetics.
Tropisetron selectively blocks serotonin (5-HT3) receptors in the central nervous system (chemoreceptor trigger zone) and peripheral nervous system (vagus nerve afferents in the GI tract), preventing serotonin-mediated signals that trigger the vomiting reflex.
May cause headache, constipation, dizziness, or fatigue. Use with caution in patients with cardiac arrhythmias or those on other QT-prolonging medications. Efficacy may decrease with repeated use due to potential tachyphylaxis. Not typically used as first-line therapy in many regions due to availability of alternatives like ondansetron.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy