Trospium
Trospium is a muscarinic antagonist medication used to treat overactive bladder and urinary incontinence. It works by blocking acetylcholine receptors in the bladder, which reduces involuntary muscle contractions and decreases the urgency and frequency of urination.
Trospium is an anticholinergic bladder medication that reduces urinary urgency and frequency by relaxing bladder smooth muscle.
Key facts at a glance
- ATC
- G04BD09
- RxNorm
- 236778
- Generic
- Trospium
- Class
- atc-g04
- Brands
- Cobenfy
- Availability
- rx
- Pregnancy
- C
- Lactation
- caution
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
use only if benefits outweigh potential risks to fetus
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimesteruse lowest effective dose
continue only if benefits outweigh risks
routine prenatal care
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid close to delivery
discontinue before delivery if possible
fetal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingdiscontinue or switch formula
not recommended during breastfeeding due to excretion in breast milk
infant monitoring for anticholinergic effects
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderlystart with low dose
use with caution due to increased sensitivity to anticholinergic effects and cognitive impairment risk
monitor cognitive function and anticholinergic side effects
Use with caution and monitor for adverse effects.
pediatric_age
children adolescentsnot recommended
not approved for use in patients under 18 years
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
severe renal impairmentreduce dose to 20mg once daily
dose reduction required in severe renal impairment (CrCl<30mL/min)
monitor renal function periodically
Use with caution and monitor for adverse effects.
hepatic_impairment
moderate hepatic impairmentuse with caution
use cautiously in moderate hepatic impairment
monitor liver function tests
Use with caution and monitor for adverse effects.
Statistics and clinical data
FDA approval year
Original FDA approval for overactive bladder
Drug class
Pharmacological classification
Common uses
Therapeutic indications
Mechanism of action
Pharmacodynamic mechanism
Treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Trospium chloride antagonizes acetylcholine at muscarinic receptors in the bladder, reducing parasympathetic stimulation and decreasing detrusor muscle contractility, which lowers bladder pressure and increases bladder capacity.
Common side effects include dry mouth, constipation, and blurred vision. Use with caution in patients with narrow-angle glaucoma, urinary retention, or severe gastrointestinal conditions. May cause drowsiness; avoid driving until effects are known.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy