Trovafloxacin
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that was used to treat various bacterial infections including respiratory tract infections, urinary tract infections, and skin infections. Due to reports of severe liver toxicity, the medication was withdrawn from most markets and is no longer available for general use.
A fluoroquinolone antibiotic that was used for bacterial infections but was withdrawn due to serious liver toxicity concerns.
Key facts at a glance
- ATC
- J01MA13
- RxNorm
- 115552
- Generic
- Trovafloxacin
- Class
- atc-j01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trovafloxacin was indicated for the treatment of community-acquired pneumonia, nosocomial pneumonia, acute sinusitis, complicated intra-abdominal infections, skin and soft tissue infections, and urinary tract infections caused by susceptible bacteria.
As a fluoroquinolone, trovafloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair, leading to bacterial cell death.
Trovafloxacin was withdrawn from the market in 2000-2001 due to rare but severe cases of hepatotoxicity leading to liver failure and transplantation. Its use is contraindicated in patients with known liver disease. Common side effects included nausea, diarrhea, headache, and dizziness. The drug carries FDA black box warnings for tendinitis, tendon rupture, and peripheral neuropathy.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy