Dihydroergotamine Mesylate
Trudhesa is a brand-name nasal spray medication containing dihydroergotamine mesylate, used for the acute treatment of migraine attacks with or without aura in adults. It works by delivering the medication through a specialized nasal delivery system to provide relief during migraine episodes.
Trudhesa is a dihydroergotamine nasal spray used to treat acute migraine attacks in adults.
Key facts at a glance
- RxNorm
- 2569837
- Generic
- Trudhesa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Acute treatment of migraine headaches with or without aura in adults. It is not used for migraine prevention or for treating other types of headaches.
Dihydroergotamine acts as an agonist at serotonin receptors, causing vasoconstriction of cranial blood vessels and inhibiting the release of inflammatory neuropeptides involved in the migraine process.
Should not be used by patients with cardiovascular disease, uncontrolled hypertension, or those who are pregnant. Common side effects may include nasal congestion, nausea, and application site reactions. Patients should not exceed the maximum recommended dose and should avoid using with other ergot derivatives or triptans due to risk of excessive vasoconstriction.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy