Plecanatide
Trulance is a prescription medication used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults. It is a guanylate cyclase-C agonist that works locally in the intestines to increase fluid secretion and improve bowel movements. This medication is typically taken once daily.
Trulance is a once-daily prescription medication for adults with chronic constipation or IBS-C that works locally in the intestines to improve stool frequency and consistency.
Key facts at a glance
- RxNorm
- 1873760
- Generic
- Trulance
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Trulance is FDA-approved for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults. It is not indicated for use in children.
Trulance (plecanatide) is a guanylate cyclase-C agonist that binds to receptors in the intestinal lining, mimicking the action of the natural hormone guanylin. This binding increases chloride and bicarbonate secretion into the intestinal lumen, which draws in water and promotes bowel movements.
Trulance should not be used in patients with known or suspected mechanical gastrointestinal obstruction. The most common side effects include diarrhea, abdominal pain, and bloating. It is contraindicated in patients younger than 6 years old due to the risk of severe dehydration. Patients should discontinue use and seek medical attention if severe diarrhea occurs.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy