Hydrocodone
Tussionex is a prescription brand-name medication that combines an antihistamine (chlorpheniramine) with an opioid cough suppressant (hydrocodone) to provide relief from cough and cold symptoms. It is primarily used to treat cough associated with allergies or upper respiratory infections in adults and children. Due to its opioid content, it is classified as a Schedule II controlled substance in the United States.
Tussionex is a prescription cough medication combining an antihistamine with an opioid to suppress cough associated with allergies or respiratory infections.
Key facts at a glance
- RxNorm
- 544165
- Generic
- Tussionex
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tussionex is indicated for the relief of cough and cold symptoms associated with allergies, hay fever, and upper respiratory infections. It is specifically formulated to address persistent cough that does not respond to milder treatments.
Tussionex contains two active ingredients: chlorpheniramine, an antihistamine that blocks histamine receptors and reduces allergic symptoms, and hydrocodone, an opioid that acts on the brain's cough center to suppress the cough reflex. The combination provides both antihistamine relief and direct cough suppression.
Tussionex contains hydrocodone, an opioid with potential for dependence, abuse, and misuse. It may cause drowsiness, dizziness, and respiratory depression. It should not be used in children under 6 years of age. Patients should avoid alcohol and other CNS depressants while taking this medication. Due to its opioid component, it requires a DEA Schedule II prescription.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy