Acetaminophen Codeine
Tylenol With Codeine is a prescription combination analgesic containing acetaminophen and codeine, used to relieve moderate to moderately severe pain. The medication combines a non-opioid pain reliever with an opioid component to provide enhanced pain relief when other treatments are inadequate. It is typically prescribed for short-term use following surgery, dental procedures, or for conditions causing significant pain.
Tylenol With Codeine is a prescription opioid combination medication for moderate to severe pain relief.
Key facts at a glance
- RxNorm
- 220586
- Generic
- Tylenol With Codeine
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for the relief of mild to moderate pain when other analgesics have not been effective, including pain from dental procedures, injuries, surgeries, and chronic conditions requiring opioid-level analgesia.
Acetaminophen reduces pain perception by inhibiting prostaglandin synthesis in the central nervous system, while codeine binds to opioid receptors and is partially metabolized to morphine, enhancing pain relief through a complementary mechanism.
Contains codeine, an opioid with risk of dependence, addiction, and potentially fatal respiratory depression. Acetaminophen poses a risk of severe liver damage with high doses or alcohol use. Not recommended for children under 12 or after tonsillectomy. May cause drowsiness—use caution when driving or operating machinery.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy