Tyrothricin
Tyrothricin is a topical antibiotic medication containing a mixture of gramicidin and tyrocidine, derived from Bacillus brevis bacteria. It is primarily used to treat superficial skin infections, minor wounds, and mucosal infections of the mouth and throat. Due to its potential to cause red blood cell destruction when absorbed systemically, it is formulated exclusively for local/topical application.
A topical antibiotic mixture used for treating superficial skin infections and mucosal infections of the mouth and throat.
Key facts at a glance
- ATC
- D06AX08
- RxNorm
- 10968
- Generic
- Tyrothricin
- Class
- atc-d06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tyrothricin is used to treat superficial skin infections, minor wounds, burns, and abrasions. It is also available in lozenge and mouthwash formulations for bacterial infections of the mouth and throat, such as pharyngitis and gingivitis. It may be combined with other agents like local anesthetics for enhanced symptomatic relief.
Tyrothricin works by disrupting bacterial cell membranes, causing cell contents to leak out and leading to bacterial cell death. Gramicidin forms ion channels in bacterial membranes, while tyrocidine interferes with membrane function and may also inhibit cell wall synthesis. The combination provides broad-spectrum activity against many gram-positive bacteria.
Tyrothricin is for topical use only and should not be injected or taken internally in significant amounts due to risk of hemolysis. Avoid application to large wound areas or use in patients with known hypersensitivity to the components. Side effects are rare but may include local irritation or allergic reactions. Consult a healthcare provider if symptoms do not improve within 7-10 days of treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy