Varenicline
Tyrvaya is a prescription nasal spray containing varenicline, approved for the treatment of dry eye disease. Unlike traditional eye drops, it is administered intranasally and works by stimulating the trigeminal parasympathetic pathway to increase natural tear production. It is used to address both the signs and symptoms of dry eye, providing an alternative for patients who have difficulty with conventional topical eye treatments.
Tyrvaya is a nasal spray medication for dry eye disease that stimulates natural tear production through the trigeminal nerve pathway.
Key facts at a glance
- RxNorm
- 2572366
- Generic
- Tyrvaya
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tyrvaya is indicated for the treatment of signs and symptoms of dry eye disease. It is prescribed to patients experiencing dryness, irritation, and discomfort due to inadequate tear production.
Tyrvaya contains varenicline, a partial nicotinic acetylcholine receptor agonist. When sprayed into the nose, it binds to trigeminal nerve receptors, stimulating the lacrimal functional unit and triggering increased production of the eye's natural tears.
Tyrvaya is administered as a nasal spray, typically one spray in each nostril twice daily. Common side effects may include sneezing, cough, throat irritation, and nasal discomfort. Patients should inform their healthcare provider of any nasal conditions, pregnancy, or breastfeeding status before use. This is a brand-name medication with no generic equivalent currently available.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy