Teplizumab
Tzield is a prescription monoclonal antibody infusion therapy designed to delay the onset of Stage 3 Type 1 Diabetes in adults and children aged 8 and older who have Stage 2 Type 1 Diabetes. Administered as a 14-day course of IV infusions, it modifies the immune system's attack on insulin-producing cells in the pancreas.
Tzield is an immunotherapy infusion that delays progression to Stage 3 Type 1 Diabetes in high-risk patients.
Key facts at a glance
- RxNorm
- 2621887
- Generic
- Tzield
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tzield is indicated to delay the onset of Stage 3 Type 1 Diabetes (clinical disease) in adults and pediatric patients 8 years of age and older who currently have Stage 2 Type 1 Diabetes (evidence of autoimmunity without hyperglycemia). It is the first therapy approved specifically for this purpose.
Tzield contains teplizumab, an anti-CD3 monoclonal antibody that binds to T cells and modulates the immune response. It is believed to work by deactivating the T cells that mistakenly attack and destroy insulin-producing beta cells in the pancreas, thereby delaying the progression to clinical diabetes.
Tzield is administered as an intravenous infusion over 30 minutes daily for 14 consecutive days. Common side effects include cytokine release syndrome, lymphopenia, rash, fever, headache, and nausea. Patients should be monitored for infusion reactions and signs of infection during treatment. A single treatment course provides the delaying benefit; retreatment safety and efficacy have not been established.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy