Tramadol
Ultram (tramadol) is a prescription pain medication used to treat moderate to moderately severe pain in adults. It works through a dual mechanism as an atypical opioid analgesic, binding to opioid receptors while also affecting neurotransmitters serotonin and norepinephrine. Due to its potential for dependence and serious side effects, it is classified as a controlled substance in many countries.
Ultram is a prescription opioid-like pain reliever for moderate to moderately severe pain that works through dual mechanisms affecting both opioid receptors and brain neurotransmitters.
Key facts at a glance
- RxNorm
- 220606
- Generic
- Ultram
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ultram is indicated for the management of moderate to moderately severe pain in adults. It may be prescribed for acute pain conditions (such as post-surgical pain or injury) or chronic pain conditions when other treatments are inadequate.
Ultram exerts its analgesic effects through two complementary mechanisms: it binds to mu-opioid receptors in the brain and spinal cord (providing pain relief), while simultaneously inhibiting the reuptake of serotonin and norepinephrine (which modulates pain perception). This dual action makes it an atypical opioid analgesic.
Ultram carries significant risks including potential for dependence, tolerance, and withdrawal symptoms. It may cause seizures, especially at higher doses, and can lead to serotonin syndrome when combined with other serotonergic drugs. It should not be used in patients with respiratory depression, uncontrolled epilepsy, or those taking MAO inhibitors. Abrupt discontinuation should be avoided. Due to abuse potential, it is a controlled substance in many jurisdictions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy