Trimethoprim Sulfadiazine
Uniprim is a brand-name antibiotic combining trimethoprim and sulfamethoxazole, two antimicrobial agents that work synergistically to inhibit bacterial growth. This medication is used to treat various bacterial infections including urinary tract infections, ear infections, bronchitis, and traveler's diarrhea, and may also be prescribed for Pneumocystis jirovecii pneumonia (PCP) prophylaxis in immunocompromised patients.
Uniprim is an antibiotic combination used to treat various bacterial infections by inhibiting bacterial folic acid synthesis.
Key facts at a glance
- RxNorm
- 894884
- Generic
- Uniprim
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Uniprim treats urinary tract infections, otitis media (ear infections), chronic bronchitis exacerbations, shigellosis, and traveler's diarrhea. It is also used for prevention of Pneumocystis jirovecii pneumonia in immunocompromised patients such as those with HIV/AIDS or undergoing chemotherapy.
Uniprim combines two agents that sequentially inhibit bacterial folate synthesis: sulfamethoxazole inhibits dihydropteroate synthase while trimethoprim inhibits dihydrofolate reductase, creating a synergistic effect that effectively blocks bacterial DNA and RNA production.
Contraindicated in patients with sulfa drug allergies, severe renal or hepatic impairment, and during late pregnancy. Common side effects include nausea, vomiting, skin rashes, and photosensitivity. Regular monitoring of blood counts is recommended for prolonged therapy. Adequate hydration is essential to prevent crystalluria. Drug interactions may occur with warfarin, methotrexate, and certain anticonvulsants.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy