Diphenhydramine
Unisom Sleep is an over-the-counter sleep aid containing doxylamine succinate, an antihistamine that promotes drowsiness. It is designed for adults experiencing occasional sleeplessness who need help falling asleep. The medication is typically taken at bedtime as needed.
Unisom Sleep is an OTC antihistamine-based sleep aid used to help adults fall asleep when experiencing occasional insomnia.
Key facts at a glance
- RxNorm
- 1093099
- Generic
- Unisom Sleep
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves occasional difficulty falling asleep due to fatigue or stress. Intended for short-term use in adults who need help initiating sleep.
Contains doxylamine succinate, an antihistamine that blocks histamine receptors in the brain, producing a sedating effect that helps facilitate sleep onset.
May cause next-day drowsiness. Should not be used with alcohol or other sedatives. Not recommended for chronic insomnia or in children. Consult a healthcare provider if used for more than 2 weeks or if pregnant/nursing.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy