Diphenhydramine
Unisom With Pain Relief is an over-the-counter medication that combines an antihistamine with a pain reliever to address both sleeplessness and minor aches or pains. This combination product is designed for temporary relief of symptoms when sleep difficulty occurs alongside mild to moderate pain.
A dual-action OTC medication combining an antihistamine sleep aid with a pain reliever for nighttime symptom relief.
Key facts at a glance
- RxNorm
- 220674
- Generic
- Unisom With Pain Relief
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for temporary relief of occasional sleeplessness when accompanied by minor aches, pains, headaches, or fever.
Combines an antihistamine with sedative properties to promote drowsiness with a pain reliever to reduce minor aches and discomfort.
Should only be used when both symptoms are present. Do not use to make a child sleepy. Consult a healthcare provider if symptoms persist beyond 7 days or worsen. May cause drowsiness; avoid driving or operating machinery until you know how it affects you.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy