Dinutuximab
Unituxin (dinutuximab) is a monoclonal antibody medication used in combination with other drugs for the treatment of high-risk neuroblastoma, a cancer that typically affects young children. It works by targeting and binding to GD2, a specific protein found on the surface of neuroblastoma cells, helping the immune system recognize and destroy cancer cells.
Unituxin is a monoclonal antibody used to treat high-risk neuroblastoma in children by targeting cancer cells for immune destruction.
Key facts at a glance
- RxNorm
- 1606279
- Generic
- Unituxin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Unituxin is indicated for the treatment of high-risk neuroblastoma in pediatric patients, typically used as part of a maintenance therapy regimen that includes granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid.
Unituxin is a chimeric monoclonal antibody that binds specifically to GD2, a disialoganglioside overexpressed on neuroblastoma cells. By targeting GD2, it marks cancer cells for destruction by the body's immune system, particularly through antibody-dependent cellular cytotoxicity (ADCC) and complement-mediated cell death.
Common side effects include severe pain requiring opioid analgesia, fever, infusion-related reactions, and peripheral neuropathy. It may also cause hypokalemia, thrombocytopenia, and hypotension. Patients require close monitoring during infusion and should not be used during pregnancy. Treatment should be administered by healthcare professionals experienced in cancer therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy