Selexipag
Uptravi (selexipag) is a prescription medication used to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs. It belongs to a class of drugs called prostacyclin receptor agonists and helps improve exercise capacity and slow disease progression in adult patients.
Uptravi is an oral medication used to treat pulmonary arterial hypertension by relaxing blood vessels in the lungs.
Key facts at a glance
- RxNorm
- 1729008
- Generic
- Uptravi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Uptravi is indicated for the treatment of pulmonary arterial hypertension (WHO Group 1) to improve exercise capacity, delay disease progression, and reduce the need for hospitalization. It may be used alone or in combination with other PAH medications.
Uptravi contains the active ingredient selexipag, which is a prostacyclin receptor agonist. It works by activating prostacyclin receptors in the pulmonary arteries, causing relaxation of the blood vessels and reducing the pressure in the lungs. This makes it easier for the heart to pump blood through the lungs.
Uptravi is typically started at a low dose and gradually increased to reduce side effects such as headache, diarrhea, jaw pain, and nausea. It should not be stopped abruptly. Common side effects include headache, diarrhea, nausea, jaw pain, muscle pain, and vomiting. Patients should inform their doctor about all medications they are taking, as drug interactions may occur.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy