Urea
Ureacin-20 is a topical dermatological preparation containing 20% urea, a naturally occurring moisturizing and keratolytic compound. It is commonly prescribed for severely dry skin conditions and helps soften and remove thickened, scaly skin while providing deep hydration to the affected areas.
Ureacin-20 is a urea-based topical cream used to moisturize dry, flaky skin and soften thickened skin lesions.
Key facts at a glance
- RxNorm
- 168479
- Generic
- Ureacin-20
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ureacin-20 is used to treat severely dry skin (xerosis), ichthyosis, eczema, psoriasis, calluses, and hyperkeratotic conditions. It is also used for rough, scaly skin on feet, elbows, and knees, as well as for nail softening before fungal treatments.
Urea acts as a humectant, drawing moisture into the skin and helping it retain water. At 20% concentration, it also has mild keratolytic properties, breaking down the protein bonds in the outer skin layer to soften and shed thickened skin. This dual action helps restore skin barrier function and improves skin texture.
Ureacin-20 is for external use only and should not be applied to broken, inflamed, or infected skin. Avoid contact with eyes and mucous membranes. It may cause mild stinging or irritation initially. The medication should be stored at room temperature away from heat and moisture. Patients with known skin sensitivities should perform a patch test before widespread use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy