Methoxsalen
Uvadex is a photosensitizing medication used in combination with UVA light therapy (PUVA) to treat certain skin conditions. It is primarily indicated for moderate to severe psoriasis and cutaneous T-cell lymphoma, as well as vitiligo. When activated by ultraviolet light, the medication helps slow skin cell proliferation and modifies immune responses in the skin.
Uvadex is a photosensitizing drug used with UVA light to treat psoriasis, cutaneous T-cell lymphoma, and vitiligo through PUVA therapy.
Key facts at a glance
- RxNorm
- 285101
- Generic
- Uvadex
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Uvadex is used to treat moderate to severe psoriasis, cutaneous T-cell lymphoma (mycosis fungoides type), and vitiligo. It is administered as part of PUVA (psoralen plus ultraviolet A) therapy, where the medication is given before controlled UVA light exposure.
Methoxsalen, the active ingredient, is a furocoumarin compound that acts as a photosensitizing agent. When activated by UVA light, it intercalates with DNA and forms cross-links, inhibiting DNA synthesis and cell division. This reduces rapid proliferation of skin cells and also modulates local immune responses in the skin.
Patients must avoid sunlight and wear UVA-blocking sunglasses for 24 hours after taking this medication due to extreme photosensitivity. PUVA therapy is associated with increased risk of skin cancer and cataracts with long-term use. Treatment should only be administered by healthcare professionals trained in PUVA therapy. Not recommended during pregnancy; may interact with other photosensitizing drugs.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy