Vaccinia Virus
Vaccinia Virus is a live virus historically used as the basis for smallpox vaccination. It belongs to the poxvirus family and has been studied for various therapeutic applications, including oncolytic virus therapy for certain cancers. The virus replicates within cells and can stimulate immune responses against targeted tissues.
Vaccinia Virus is a live viral agent used primarily for smallpox prevention and being investigated for cancer treatment.
Key facts at a glance
- RxNorm
- 1668221
- Generic
- Vaccinia Virus
- Class
- unclassified
- Brands
- Jynneos
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Historically used for smallpox vaccination; investigational use in oncolytic therapy for certain solid tumors; studied as a viral vector for gene therapy and vaccine development.
As a live virus, it infects and replicates within host cells, potentially destroying tumor cells while also stimulating immune responses against the targeted tissue.
Live vaccinia virus is contraindicated in immunocompromised individuals and those with certain skin conditions. Replication-competent viral vectors require careful handling. Use in clinical settings requires specialized expertise and containment measures.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy