Estradiol Vaginal Tablets
Vagifem is a vaginal estradiol insert used to treat symptoms of vaginal atrophy (genitourinary syndrome of menopause), including vaginal dryness, itching, burning, and pain during intercourse. It delivers low-dose estrogen directly to vaginal tissues to restore thickness and moisture. This medication is typically prescribed for postmenopausal women experiencing genitourinary symptoms related to declining estrogen levels.
Vagifem is a local vaginal estrogen therapy used to relieve symptoms of vaginal atrophy in postmenopausal women.
Key facts at a glance
- RxNorm
- 152483
- Generic
- Vagifem
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of urogenital symptoms of menopause, including vaginal dryness, irritation, itching, burning, and dyspareunia (painful intercourse) caused by vaginal atrophy. Also used to restore vaginal pH and maintain healthy vaginal tissue.
Vagifem contains estradiol, a form of estrogen. It delivers a low dose of estrogen directly to vaginal tissues via an insert or tablet, replenishing declining hormone levels and stimulating tissue growth, lubrication, and restoration of the vaginal lining.
This medication is for vaginal use only. It is a local therapy with minimal systemic absorption compared to oral estrogen. Patients with certain cancers, undiagnosed vaginal bleeding, or known/suspected pregnancy should not use this product. As with all estrogen therapies, use at the lowest effective dose for the shortest duration consistent with treatment goals. Regular follow-up with a healthcare provider is recommended.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy