Valganciclovir
Valganciclovir is an antiviral medication used primarily to treat and prevent cytomegalovirus (CMV) infections in immunocompromised patients, particularly those with HIV/AIDS or organ transplant recipients. It is a prodrug that converts to ganciclovir in the body, where it inhibits viral DNA synthesis to suppress CMV replication.
Antiviral medication for treating and preventing CMV infections in immunocompromised patients, such as those with HIV/AIDS or organ transplants.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- J05AB14
- RxNorm
- 275891
- Generic
- Valganciclovir
- Class
- atc-j05
- Brands
- Valcyte
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of CMV retinitis in immunocompromised patients, including those with AIDS. Prevention of CMV disease in solid organ transplant recipients. May also be used for other CMV infections in vulnerable patient populations.
Valganciclovir is a prodrug of ganciclovir. After oral administration, it is converted to ganciclovir by intestinal and hepatic enzymes. Ganciclovir then inhibits viral DNA polymerase, preventing replication of CMV.
Significant toxicities include bone marrow suppression (anemia, neutropenia, thrombocytopenia), nephrotoxicity, and neurological effects. Requires dose adjustment in renal impairment. Teratogenic - contraindicated in pregnancy. May cause infertility. Regular monitoring of blood counts and renal function is required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy