Conivaptan
Vaprisol is an injectable vasopressin receptor antagonist used in hospitalized patients to treat euvolemic hyponatremia, a condition of dangerously low sodium levels. By blocking vasopressin receptors in the kidneys, it increases water excretion while preserving sodium, helping restore normal electrolyte balance.
Vaprisol is an IV hospital medication that raises low sodium levels by helping the kidneys remove excess water from the body.
Key facts at a glance
- RxNorm
- 616622
- Generic
- Vaprisol
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Vaprisol is primarily used to treat euvolemic hyponatremia (low serum sodium) in hospitalized patients, including those with conditions like syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure.
Vaprisol blocks vasopressin V1A and V2 receptors, particularly in the kidneys, preventing water reabsorption and promoting aquaresis—the excretion of free water without loss of electrolytes.
Vaprisol is administered intravenously in an inpatient setting only. It requires careful sodium monitoring to avoid overcorrection (osmotic demyelination syndrome). Common side effects include infusion site reactions, headache, and electrolyte abnormalities. It is contraindicated in patients with hypovolemic hyponatremia or anuria.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy