Varenicline
Varenicline is a prescription medication specifically designed to help adults quit smoking by reducing nicotine cravings and blocking the pleasurable effects of cigarettes. It works by partially stimulating nicotine receptors in the brain, which helps ease withdrawal symptoms while preventing relapse if a person smokes again.
Varenicline is a smoking cessation aid that reduces cravings and blocks nicotine's effects by acting on specific brain receptors.
Key facts at a glance
- ATC
- N07BA03
- RxNorm
- 591622
- Generic
- Varenicline
- Class
- atc-n07
- Brands
- Tyrvaya, Chantix
- Availability
- rx
- Lactation
- unknown
- Routes
- nasal, oral
- Forms
- spray, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Varenicline is indicated as an aid to smoking cessation treatment in adults. It is typically prescribed as part of a comprehensive program that may include counseling and support to help patients quit tobacco use.
Varenicline binds selectively to α4β2 neuronal nicotinic acetylcholine receptors in the brain, where it acts as a partial agonist. This means it stimulates these receptors less than nicotine would, reducing withdrawal cravings while simultaneously blocking nicotine from binding if the patient resumes smoking.
Common side effects include nausea, headache, and vivid dreams. Patients should be monitored for mood and behavior changes, including depression and suicidal ideation. Treatment usually begins 1 week before the quit date and continues for 12 weeks, though some patients may need extended therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy