Varicella Zoster Virus Glycoprotein E
Varicella Zoster Virus Glycoprotein E (gE) is a recombinant viral surface protein used as the primary antigen in the recombinant shingles vaccine (RZV/Shingrix). It stimulates immune responses against varicella zoster virus to prevent herpes zoster (shingles) and its complications, particularly in adults aged 50 and older and immunocompromised individuals.
A recombinant viral glycoprotein antigen that forms the basis of shingles vaccination by inducing protective immunity against varicella zoster virus.
Key facts at a glance
- RxNorm
- 1986821
- Generic
- Varicella Zoster Virus Glycoprotein E
- Class
- unclassified
- Brands
- Shingrix
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection, prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of herpes zoster (shingles) and postherpetic neuralgia in adults 50 years and older, and in immunocompromised adults 18 years and older at increased risk of shingles.
As a recombinant glycoprotein antigen, it mimics the natural VZV surface protein to trigger robust humoral and cellular immune responses, generating antibodies and T-cells that protect against varicella zoster virus reactivation.
Administered as a two-dose series intramuscularly. Commonly causes injection site pain, myalgia, and fatigue. Contraindicated in individuals with severe allergic reactions to any vaccine component. Not a treatment for active shingles infection.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy