Rolapitant
Varubi (rolupitant) is a prescription antiemetic medication that belongs to a class of drugs called NK1 receptor antagonists. It is used to prevent delayed nausea and vomiting in adults and children experiencing these symptoms following cancer chemotherapy treatments.
Varubi is an anti-nausea medication that helps prevent delayed chemotherapy-induced nausea and vomiting by blocking NK1 receptors.
Key facts at a glance
- RxNorm
- 1673368
- Generic
- Varubi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Varubi is indicated for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy in adults and pediatric patients aged 6 months and older.
Varubi is an NK1 (neurokinin-1) receptor antagonist that works by blocking substance P, a key neurotransmitter involved in triggering the vomiting reflex. By inhibiting this pathway, it helps prevent nausea and vomiting during the delayed phase (typically 2-5 days post-chemotherapy).
Varubi is taken orally as a single dose prior to chemotherapy. It should not be used as a single-agent antiemetic and is typically given with other antiemetics. Common side effects may include headache, fatigue, and hiccups. Patients should inform their healthcare provider of all current medications, as drug interactions can occur. Safety in pregnancy has not been established.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy