Velmanase Alfa
Velmanase Alfa is a recombinant human alpha-mannosidase enzyme replacement therapy used to treat alpha-mannosidosis, a rare lysosomal storage disorder. It works by supplementing the deficient enzyme to help break down accumulated mannose-containing oligosaccharides in cells. This medication is specifically indicated for patients with confirmed alpha-mannosidosis diagnosis.
Velmanase Alfa is an enzyme replacement therapy for alpha-mannosidosis that helps break down accumulated oligosaccharides by supplementing deficient alpha-mannosidase enzyme.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- A16AB15
- RxNorm
- 2630725
- Generic
- Velmanase Alfa
- Class
- atc-a16
- Brands
- Lamzede
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Velmanase Alfa is indicated for the treatment of non-neurological manifestations in patients with confirmed alpha-mannosidosis, a rare autosomal recessive lysosomal storage disease caused by deficiency of the alpha-mannosidase enzyme.
As a recombinant form of human alpha-mannosidase, Velmanase Alfa catalyzes the hydrolysis of mannose-containing oligosaccharides that accumulate in the lysosomes of patients with alpha-mannosidosis due to reduced endogenous enzyme activity.
Velmanase Alfa is administered via intravenous infusion. Hypersensitivity reactions may occur during treatment. Patients should be monitored appropriately during infusions. This therapy addresses systemic manifestations but does not cross the blood-brain barrier.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy