Sucroferric Oxyhydroxide
Velphoro (ferric pyrophosphate citrate) is a prescription iron replacement medication used to treat iron deficiency anemia in adults with chronic kidney disease (CKD) who are on dialysis. Unlike traditional iron supplements taken orally or intravenously, Velphoro is added directly to the dialysate solution during hemodialysis, allowing iron to be delivered into the bloodstream during treatment. This medication helps replenish iron stores to support red blood cell production in patients whose kidneys can no longer adequately manage iron metabolism.
Velphoro is an iron replacement therapy specifically designed for iron deficiency anemia in chronic kidney disease patients on hemodialysis, delivered directly through the dialysis solution.
Key facts at a glance
- RxNorm
- 1484290
- Generic
- Velphoro
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) who are undergoing hemodialysis. It is specifically indicated for patients on dialysis who have low serum ferritin and transferrin saturation levels indicating iron deficiency.
Velphoro is a soluble iron compound (ferric pyrophosphate citrate) that is added to the dialysate solution. During hemodialysis, iron is transferred from the dialysate across the dialyzer membrane into the patient's bloodstream. This allows direct delivery of iron to replenish iron stores and support erythropoiesis (red blood cell production), bypassing the gastrointestinal tract.
Velphoro is for patients on hemodialysis only—it is not for oral use or peritoneal dialysis. Common side effects may include hypersensitivity reactions, hypotension, and procedural complications related to dialysis. Iron parameters (ferritin, transferrin saturation) should be monitored regularly. Patients with known iron overload disorders should not use Velphoro. Always follow healthcare provider instructions regarding dosing and monitoring.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy