Vericiguat
Vericiguat is a soluble guanylate cyclase (sGC) stimulator used to treat adults with symptomatic chronic heart failure with reduced ejection fraction. It works by enhancing the nitric oxide signaling pathway to increase production of cyclic GMP (cGMP), a molecule that helps relax and widen blood vessels, improving blood flow and reducing the heart's workload.
Vericiguat is a heart failure medication that stimulates an enzyme to improve blood flow and reduce cardiovascular events in patients with reduced ejection fraction.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- C01DX22
- RxNorm
- 2475830
- Generic
- Vericiguat
- Class
- atc-c01
- Brands
- Verquvo
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Vericiguat is indicated to reduce the risk of cardiovascular death and heart failure hospitalization in adults with symptomatic chronic heart failure with reduced ejection fraction (HFrEF).
Vericiguat directly stimulates soluble guanylate cyclase (sGC), an enzyme that converts GTP to cyclic GMP (cGMP). This enhances the nitric oxide pathway, increasing intracellular cGMP levels, which promotes vasodilation, improves blood flow, and reduces cardiac workload.
Vericiguat is contraindicated during pregnancy due to potential fetal harm. It may cause hypotension and should be used with caution in patients on PDE-5 inhibitors or nitrates. Regular monitoring of renal function may be needed. Tablets are taken once daily with food.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy