Eluxadoline
Viberzi (eluxadoline) is a prescription medication used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults. It works by acting on opioid receptors in the gut to reduce bowel contractions and fluid secretion, which helps decrease diarrhea and abdominal pain.
Viberzi is used to treat IBS-D by acting locally on gut opioid receptors to reduce diarrhea and abdominal discomfort.
Key facts at a glance
- RxNorm
- 1653787
- Generic
- Viberzi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Viberzi is FDA-approved for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adult patients. It is specifically indicated for long-term management of this condition.
Viberzi contains eluxadoline, a mixed mu-opioid receptor agonist and delta-opioid receptor antagonist. It acts locally in the gastrointestinal tract, reducing intestinal secretions and motility while modulating pain responses without significant systemic absorption.
Viberzi is contraindicated in patients without a gallbladder (cholecystectomy) due to increased risk of serious pancreas (pancreatitis) and bile duct (sphincter of Oddi) problems. Alcohol use should be avoided during treatment. Common side effects include constipation, nausea, and abdominal pain. Patients should seek immediate medical attention for symptoms of pancreatitis or sphincter of Oddi spasm such as severe abdominal pain radiating to the back, with or without nausea and vomiting.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy