Vilazodone
Vilazodone is an antidepressant medication used to treat major depressive disorder (MDD) in adults. It works by enhancing serotonergic activity in the central nervous system through selective serotonin reuptake inhibition and partial agonism at serotonin 5-HT1A receptors.
Vilazodone is an antidepressant used to treat major depressive disorder by increasing serotonin activity in the brain.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N06AX24
- RxNorm
- 1086769
- Generic
- Vilazodone
- Class
- atc-n06
- Brands
- Viibryd
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Vilazodone is FDA-approved for the treatment of major depressive disorder (MDD) in adults.
Vilazodone is a selective serotonin reuptake inhibitor (SSRI) with partial agonist activity at serotonin 5-HT1A receptors, enhancing serotonergic neurotransmission in the central nervous system.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults and adolescents. Vilazodone may cause serotonin syndrome when combined with other serotonergic agents. Common side effects include nausea, diarrhea, insomnia, and headache. Avoid use with MAO inhibitors and allow adequate washout period when switching between antidepressants.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy