Vitamin K2
Vitamin K2 (menaquinone) is a fat-soluble vitamin essential for activating proteins that regulate blood clotting and support bone health. It is primarily used to promote bone mineralization and cardiovascular health by helping direct calcium to bones while preventing its accumulation in blood vessels.
Vitamin K2 supports bone and heart health by activating proteins that manage calcium metabolism in the body.
Key facts at a glance
- ATC
- unclassified
- RxNorm
- unknown
- Generic
- Vitamin K2
- Class
- unclassified
- Brands
- —
- Availability
- otc
- Pregnancy
- A
- Lactation
- safe
- Half-life (h)
- 48
- Onset (min)
- 0
- Duration (h)
- 0
- Routes
- oral
- Forms
- capsule, tablet, softgel
- Regions
- United States, European Union, Canada, Australia, Japan
- Monitoring
- coagulation parameters if on anticoagulants, bone mineral density
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Vitamin K2 is used to support bone health and reduce the risk of osteoporosis-related fractures. It is also taken to support cardiovascular health by helping prevent calcium deposition in arteries. Healthcare providers may recommend it alongside vitamin D for enhanced bone-building effects.
Vitamin K2 activates osteocalcin, a protein that binds calcium to the bone matrix, and matrix Gla protein (MGP), which inhibits calcium deposition in blood vessels and soft tissues. By activating these proteins, K2 helps ensure calcium is properly utilized for bone strength rather than accumulating in arterial walls.
Vitamin K2 is generally well-tolerated. Individuals taking anticoagulant medications (such as warfarin) should consult their healthcare provider before use, as Vitamin K can interfere with these drugs. Natural sources include fermented foods, certain cheeses, egg yolks, and meat. It is fat-soluble, so it should be taken with a meal containing fat for optimal absorption.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy