Voclosporin
Voclosporin (Lupkynis) is a prescription immunosuppressant medication classified as a calcineurin inhibitor. It is specifically approved for treating adults with active lupus nephritis, a serious kidney complication of systemic lupus erythematosus. By suppressing immune cell activation, it helps reduce inflammation and proteinuria (protein in urine) associated with this condition.
Voclosporin is an immunosuppressant used to treat active lupus nephritis by inhibiting calcineurin to reduce immune-mediated kidney inflammation.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L04AD03
- RxNorm
- 2475166
- Generic
- Voclosporin
- Class
- atc-l04
- Brands
- Lupkynis
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Voclosporin is indicated for the treatment of adult patients with active lupus nephritis (class III-V) to reduce proteinuria and improve renal outcomes in combination with other immunosuppressive therapy.
As a calcineurin inhibitor, voclosporin blocks the calcineurin pathway, which is involved in T-cell activation. This suppresses lymphocyte-mediated immune responses that contribute to kidney inflammation in lupus nephritis.
Common side effects include decreased glomerular filtration rate, hypertension, diarrhea, headache, and anemia. Patients require regular monitoring of blood pressure, kidney function, and lipid levels. Use is contraindicated in patients with severe renal impairment or taking strong CYP3A4 inhibitors. May increase infection risk including viral reactivation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy