Vonoprazan
Vonoprazan is a potassium-competitive acid blocker (P-CAB) used to treat conditions like GERD, gastric ulcers, and duodenal ulcers by reducing stomach acid production.
Vonoprazan is a next-generation acid-suppressing medication that blocks the stomach's proton pump to treat acid-related conditions like GERD and ulcers.
Key facts at a glance
- ATC
- A02BC08
- RxNorm
- 2604577
- Generic
- Vonoprazan
- Class
- atc-a02
- Brands
- Voquezna
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of erosive GERD, gastric ulcers, duodenal ulcers, and prevention of NSAID-induced ulcers; used as part of combination therapy for H. pylori eradication
Vonoprazan competitively inhibits the H+, K+-ATPase enzyme (proton pump) at the gastric parietal cell surface, blocking both basal and stimulated acid secretion in a potassium-competitive manner, providing rapid and sustained acid suppression
May cause headache, diarrhea, constipation, and nausea; use with caution in patients with liver impairment; has fewer drug interactions compared to traditional PPIs due to CYP-independent metabolism; not recommended during pregnancy without careful consideration of benefits versus risks
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy