Glucarpidase
Voraxaze is a prescription enzyme used to treat toxic methotrexate levels in patients with methotrexate-induced kidney dysfunction. It works by breaking down methotrexate into inactive metabolites that can be eliminated from the body.
Voraxaze is an enzyme therapy that rapidly reduces dangerous methotrexate levels in patients with impaired kidney function.
Key facts at a glance
- RxNorm
- 1242132
- Generic
- Voraxaze
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Voraxaze is indicated for the treatment of toxic methotrexate levels (methotrexate-induced acute kidney injury) in patients with delayed methotrexate clearance due to impaired renal function.
Voraxaze contains the enzyme glucarpidase, which hydrolyzes methotrexate into inactive metabolites that are then cleared by the body independent of renal function, rapidly reducing toxic methotrexate concentrations.
Voraxaze is administered as a single intravenous injection. It should not be given intrathecally. Leucovorin, which also reduces methotrexate toxicity, should not be administered within 2 hours of Voraxaze due to potential interference.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy