Vortioxetine
Vortioxetine is a multimodal antidepressant used to treat major depressive disorder in adults. It works by increasing serotonin activity in the brain through multiple mechanisms, including inhibition of serotonin reuptake and modulation of various serotonin receptors.
An antidepressant medication for adults with major depressive disorder that enhances serotonin activity through multiple mechanisms.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N06AX26
- RxNorm
- 1455099
- Generic
- Vortioxetine
- Class
- atc-n06
- Brands
- Trintellix
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of major depressive disorder (MDD) in adults
Enhances serotonergic activity in the central nervous system through serotonin (5-HT) reuptake inhibition and activity at multiple 5-HT receptor subtypes, providing a multimodal mechanism of action
Antidepressants may take several weeks to show full effect. Not approved for use in children and adolescents. Should be discontinued gradually to avoid discontinuation syndrome. May increase risk of bleeding, especially when combined with NSAIDs, aspirin, or anticoagulants.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy