Velaglucerase Alfa
Vpriv (velaglucerase alfa) is a prescription medication used for enzyme replacement therapy in patients with Type 1 Gaucher disease, a rare genetic disorder where fatty substances accumulate in cells due to deficiency of the enzyme glucocerebrosidase. It is administered as an intravenous infusion to help reduce organ enlargement, improve blood counts, and address bone complications associated with this condition.
Vpriv is an enzyme replacement therapy for Type 1 Gaucher disease that helps break down accumulated fatty substances in cells.
Key facts at a glance
- RxNorm
- 901809
- Generic
- Vpriv
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Vpriv is indicated for long-term enzyme replacement therapy in patients with Type 1 Gaucher disease. It is used to treat symptoms including enlarged liver and spleen, anemia, low platelet counts, and bone disease such as bone pain and osteonecrosis.
Vpriv contains velaglucerase alfa, a recombinant form of the enzyme glucocerebrosidase. It works by replacing the deficient natural enzyme, allowing it to be taken up by cells and break down accumulated glucocerebroside, thereby reducing the burden of this fatty substance in affected tissues.
Vpriv is administered via intravenous infusion every 2 weeks by a healthcare professional. Common side effects may include infusion-related reactions, headache, dizziness, and fatigue. Patients should be monitored for signs of hypersensitivity reactions. Treatment should be initiated and supervised by a physician experienced in managing Gaucher disease.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy