Voretigene Neparvovec
Vyjuvek is a topical gene therapy gel designed to treat dystrophic epidermolysis bullosa (DEB), a rare genetic skin disorder characterized by fragile skin that blisters and tears easily from minor trauma. It delivers a functional copy of the COL7A1 gene directly to wounds, enabling the skin to produce type VII collagen and promoting healing.
A topical gene therapy gel for treating fragile, blistering skin in patients with dystrophic epidermolysis bullosa.
Key facts at a glance
- RxNorm
- 2637763
- Generic
- Vyjuvek
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Vyjuvek is indicated for the treatment of dystrophic epidermolysis bullosa (DEB), a rare genetic condition where patients lack functional type VII collagen, leading to fragile skin that blisters and tears easily from minor friction or trauma.
Vyjuvek is a non-viral gene therapy gel that delivers a functional copy of the COL7A1 gene directly to wounds. Once applied, the gene enables skin cells to produce type VII collagen, a critical protein that helps anchor the layers of skin together and promotes wound healing.
Vyjuvek is applied topically to wounds and should not be used on active infections, in or around the eyes, or on mucosal surfaces. As a brand-name medication, it is manufactured by Krystal Biotech and represents a novel approach to treating the underlying cause of DEB rather than just managing symptoms.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy