Bremelanotide
Vyleesi (bremelanotide) is a prescription medication used to treat hypoactive sexual desire disorder (HSDD) in premenopausal women. It is a melanocortin receptor agonist administered as a self-injected subcutaneous dose approximately 45 minutes before anticipated sexual activity to help increase sexual desire.
Vyleesi is an injectable medication for premenopausal women with HSDD that works by activating melanocortin receptors to help increase sexual desire.
Key facts at a glance
- RxNorm
- 2176317
- Generic
- Vyleesi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women, characterized by low sexual desire that causes personal distress.
Vyleesi is a melanocortin receptor agonist that activates melanocortin receptors in the central nervous system. This action is believed to modulate pathways involved in sexual response, helping to restore sexual desire.
Administered by self-injection under the skin (subcutaneous) in the abdomen or thigh approximately 45 minutes before anticipated sexual activity. Should not be used more than once in 24 hours or exceed 8 injections per month. Contraindicated in patients with uncontrolled hypertension or known cardiovascular disease. Common side effects may include nausea, flushing, headache, and injection site reactions.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy