Vyloy
Vyloy (zolbetuximab) is a prescription medication that targets Claudin 18.2 (CLDN18.2) proteins on cancer cells. It is used to treat certain types of gastric (stomach) cancer and gastroesophageal junction adenocarcinoma in adults whose tumors express CLDN18.2 and are HER2-negative.
Vyloy is a targeted therapy monoclonal antibody used to treat CLDN18.2-positive gastric and gastroesophageal junction cancers.
Key facts at a glance
- RxNorm
- 2695877
- Generic
- Vyloy
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of advanced or metastatic HER2-negative gastric adenocarcinoma and gastroesophageal junction (GEJ) adenocarcinoma in adults whose tumors express the Claudin 18.2 (CLDN18.2) protein
Vyloy is a monoclonal antibody that binds to CLDN18.2 proteins on cancer cells, which are commonly found on gastric cancer cells, allowing the immune system to recognize and destroy the cancer cells
This is a targeted therapy administered via intravenous infusion. Common side effects include nausea, vomiting, fatigue, and decreased appetite. Patients should be monitored for infusion-related reactions. Treatment decisions should be made in consultation with an oncologist based on individual patient factors and tumor characteristics.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy