Pitolisant
Wakix (pitolisant) is a prescription wakefulness-promoting agent used to treat excessive daytime sleepiness and cataplexy in adults with narcolepsy. It works by blocking histamine H3 receptors, which increases the release of histamine and other neurotransmitters that promote wakefulness in the brain.
Wakix is a prescription medication for adults with narcolepsy to reduce excessive daytime sleepiness and cataplexy.
Key facts at a glance
- RxNorm
- 2197885
- Generic
- Wakix
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Wakix is FDA-approved for the treatment of excessive daytime sleepiness (EDS) and cataplexy in adults with narcolepsy.
Wakix is a histamine H3 (H3) receptor antagonist/inverse agonist. By blocking H3 receptors, it enhances the release of histamine, dopamine, norepinephrine, and acetylcholine—neurotransmitters that promote wakefulness and alertness in the brain.
Wakix is a Schedule IV controlled substance. Common side effects may include insomnia, headache, and nausea. Patients should inform their doctor about all medications they are taking, as drug interactions may occur. Wakix is not recommended during pregnancy or breastfeeding. Dosage is typically started low and gradually increased to reduce side effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy