Bupropion
Wellbutrin (bupropion) is an atypical antidepressant used primarily to treat major depressive disorder and seasonal affective disorder. Unlike most antidepressants, it works by inhibiting the reuptake of norepinephrine and dopamine rather than targeting serotonin. It may also be prescribed as an aid to smoking cessation under the brand name Zyban.
Wellbutrin is an antidepressant that treats depression by affecting norepinephrine and dopamine levels in the brain.
Key facts at a glance
- RxNorm
- 42568
- Generic
- Wellbutrin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of major depressive disorder (MDD) and prevention of seasonal affective disorder (SAD). Also approved as Zyban for smoking cessation.
Functions as a norepinephrine-dopamine reuptake inhibitor (NDRI), increasing these neurotransmitters in the brain by preventing their reabsorption.
Does not cause sexual side effects common to SSRIs. Contraindicated in patients with seizure disorders or eating disorders. May increase blood pressure. Should not be used with MAO inhibitors. Available in immediate-release, sustained-release (SR), and extended-release (XL) formulations.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy