Roflumilast
Winrevair (sotatercept) is a prescription medication used to treat pulmonary arterial hypertension (PAH) in adults. It is an activin receptor fusion protein that helps improve exercise capacity in patients with WHO Group 1 PAH. Winrevair is administered as a subcutaneous injection and is typically used in combination with other PAH therapies.
Winrevair is an injectable PAH medication that improves exercise capacity in adults with pulmonary arterial hypertension.
Key facts at a glance
- RxNorm
- 2678938
- Generic
- Winrevair
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Winrevair is indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group 1) to improve exercise capacity, improve WHO functional class, and reduce the risk of clinical worsening events. It is approved for use in adult patients.
Winrevair is a fusion protein that acts as an activin signaling inhibitor. It binds to activin ligands, preventing their interaction with activin receptors. This mechanism helps rebalance BMPR2 and other signaling pathways that are often dysregulated in PAH, promoting improved vascular remodeling and cardiopulmonary function.
Winrevair is administered as a subcutaneous injection, typically once every 3 weeks. Common side effects may include headache, telangiectasia, peripheral edema, and dizziness. Patients should be monitored for hemoglobin and platelet changes during treatment. It should not be used during pregnancy. Winrevair is generally used in combination with other PAH therapies and requires appropriate training for self-administration.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy