Crizotinib
Xalkori (crizotinib) is a prescription medication used to treat certain types of advanced non-small cell lung cancer (NSCLC) in patients whose tumors have specific genetic mutations. It is specifically indicated for patients whose tumors are ALK-positive or ROS1-positive, which are determined through genetic testing prior to treatment.
Xalkori is an oral targeted therapy for ALK-positive and ROS1-positive non-small cell lung cancer.
Key facts at a glance
- RxNorm
- 1148499
- Generic
- Xalkori
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Xalkori is used to treat advanced non-small cell lung cancer (NSCLC) in patients whose tumors test positive for ALK (anaplastic lymphoma kinase) or ROS1 gene rearrangements. It is typically prescribed when the cancer has spread to other parts of the body.
Xalkori is a tyrosine kinase inhibitor that works by blocking the activity of ALK and ROS1 proteins. These proteins promote cancer cell growth and survival, and by inhibiting them, Xalkori helps slow or stop the progression of lung cancer cells.
Xalkori is only prescribed after confirming ALK or ROS1 positivity through biomarker testing. Common side effects may include vision changes, nausea, diarrhea, and liver enzyme elevations. Patients should discuss all medications and health conditions with their healthcare provider before starting treatment, as drug interactions can occur.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy