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Xenleta (lefamulin) is an antibacterial prescription medication used to treat community-acquired bacterial pneumonia (CABP) in adults. It belongs to the pleuromutilin antibiotic class and is available in both oral and intravenous formulations, offering flexibility in treatment administration.
Xenleta is an antibiotic used to treat pneumonia in adults, available as an oral tablet or intravenous injection.
Key facts at a glance
- RxNorm
- 2198949
- Generic
- Xenleta
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of community-acquired bacterial pneumonia (CABP) caused by susceptible gram-positive and gram-negative bacteria in adult patients. It is not indicated for pneumonia acquired in healthcare settings or for ventilator-associated pneumonia.
Xenleta is a pleuromutilin antibiotic that works by inhibiting bacterial protein synthesis. It binds to the peptidyl transferase center of the bacterial 50S ribosomal subunit, blocking the formation of peptide bonds and preventing bacterial growth.
Xenleta may cause QT prolongation and should be used cautiously in patients with certain heart conditions or those taking other QT-prolonging drugs. Liver function monitoring may be needed during treatment. Common side effects include diarrhea, nausea, and injection site reactions. Always complete the full course of therapy as prescribed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy